Idelalisib (CAL-101, GS-1101) is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages.
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【Aliases】Idelalisib
【CAS No.】870281-82-6
【Catelog No.】CB37
【Purity】99%
【Formula】C22H18FN7O
【Molecular Weight】415.42
【Brief Introduction】
【Introduction】
Treatment of chronic lymphocytic leukemia
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